Welcome to the PhD. Pharmaceutical Chemistry

This course is designed to recognize and utilize the major reaction mechanisms, especially those involving intermediates: Electrophilic addition, elimination, oxidation-reduction, electrophilic aromatic substitution free radical. Understanding of organic reaction mechanisms involving radical reactions and application of radical reaction mechanisms in drug synthesis is discussed by exploring specific examples that is relevant to medicinal chemistry.
To extend knowledge of important reaction mechanisms, building upon Organic Reaction Mechanism I, II and III courses. Strategies in organic synthesis, reactivity, molecular rearrangements, reaction intermediates, enzymatic reactions, stereoelectronic effects are elucidated.
Application of Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) techniques in determination of structure of organic compounds, pharmaceuticals is presented. This course is based on solving various examples of both simple and complex chemical structures by using these instrumental methods.